Bambec is at least as effective as oral terbutaline, salbutamol, and theophylline, with the advantage of convenient once-daily dosing.
| 1. Persson G et al. Curr Ther Res 1995; 56: 457–65 |
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Bambec 20 mg once daily and terbutaline 5 mg three-times daily produced similar improvements in lung function (measured by PEF values) but Bambec caused better overall improvement in asthma symptom scores and less uneasiness.
Efficancy of Bambec: asthma symptom scores Bambec versus terbutaline
Adapted from Persson et al., 1995.
Side-effect profile of Bambec: adverse event scores Bambec versus terbutaline
Adapted from Persson et al., 1995. |
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| 2. Gunn SD, et al. Eur J Clin Pharmacol 1995; 48: 23–8 |
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Bambec 20 mg once daily and salbutamol CR 8 mg twice daily were equally effective in controlling nocturnal asthma symptoms and improving lung function measurements. Bambec was associated with significantly less tremor than salbutamol CR.
Efficacy of Bambec: sleep disturbance in asthma Bambec versus salbutamol
Adapted from Gunn et al., 1995
Side-effect profile of Bambec: tremor scores Bambec versus salbutamol
Adapted from Gunn et al., 1995. |
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| 3. Bone MF, et al. Eur Respir J 1995; 8 (Suppl. 19): 72S
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This study compared Bambec with sustained release theophylline. Following a run-in period, patients received theophylline twice daily at 150 mg for 4 days, then 300 mg for 10 days, or Bambec once daily at 10 mg for 4 days and 20 mg for 10 days (Period I). A greater increase in PEF was observed in the Bambec group than in the theophylline group.
In period II, patients continued to receive Bambec 20 mg twice daily or received theophylline 300, 400, or 600 mg optimised to produce a plasma concentration of 10–20 mg/L. Similar increases in PEF were observed.
More patients withdrew from the study due to adverse events in the theophylline group than in the Bambec group (39% versus 14%; p < 0.001).
Efficacy of Bambec: lung function
Bambec versus theophylline
In period I, patients received theophylline twice daily at 150 mg for 4 days, then 300 mg for 10 days, or Bambec once daily at 10 mg for 4 days and 20 mg for 10 days.
Adapted from Bone et al., 1995. |
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