| 1. Knight A, et al. Eur Respir J 1990; 3 (Suppl. 10): 321s |
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Bambec 10 mg and 20 mg but not 5 mg produced significant increases in both morning and evening peak expiratory flow rate values in elderly patients.
Bambec improves lung function in elderly patients with asthma
Mean (± SD) peak expiratory flow rates 12 hours (morning) and 24 hours (evening) after administration of Bambec 10 mg or 20 mg or placebo for 1 week to 73 elderly asthmatic patients. (5 mg data are not shown.)
Adapted from Knight et al., 1990. |
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| 2. McDonald CF et al. J Asthma 1997; 34: 53–9 |
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Bambec 10 mg and 20 mg once daily in the evening was compared with terbutaline 3 mg three times a day in 84 elderly patients with chronic reversible obstructive airways disease. All treatments were more effective than placebo. Bambec 20 mg significantly increased morning peak expiratory flow rate values compared with terbutaline.
Efficacy of Bambec in the elderly: lung function
Mean (± SEM) morning and evening PEF in 66 elderly patients with chronic reversible airways disease who completed 4 consecutive treatment periods, each of 2 weeks, with placebo, terbutaline, Bambec 10 mg, and Bambec 20 mg.
Adapted from McDonald et al., 1997. |
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| 3. Sitar DS, et al. Clin Pharmacol Ther 1992; 52: 297–306 |
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| Elderly patients had a lower apparent clearance of terbutaline, which was not associated with any differences in the efficacy or tolerability of Bambec. |
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