Correct use of a pMDI in combination with NebuChamber^® results in a high proportion of the metered dose delivered as fine droplets (< 4.7 µm) (Berg et al, 1998). Fine particle dose is considered to be proportional to the dose available to the lungs.

This study compared the dose output of fine droplets from NebuChamber. The output of fine particles was calculated based on the dose delivered by the valved holding chambers when connected to a ventilator set to simulate the breathing pattern of a young child. NebuChamber delivered a high portion of fine droplets.

The drug used in this study was budesonide. Adapted from Berg et al (1998).

Reference

Berg E, et al. In vitro performance of three combinations of valved holding chambers and pressurized metered dose inhalers for treatment in children. Eur Respir J 1998;12:472-6.