Washing procedures affect the charge on traditional plastic holding chambers; therefore, washing may cause variation in the dose delivered. Washing procedures have no effect on the delivery of drug from NebuChamber^® because it is entirely free from electrostatic charge.

Regardless of whether NebuChamber was new, primed with 15 doses of drug aerosol, or washed and rinsed, NebuChamber consistently provided an environment where over half of the drug-containing droplets remained airborne (aerosol half-life) for nearly 30 seconds (Berg et al, 1998).

The drug used in this study was budesonide. Adapted from Berg et al (1998).

Reference

Berg E, et al. In vitro performance of three combinations of valved holding chambers and pressurized metered dose inhalers for treatment in children. Eur Respir J 1998;12:472-6.