| 1. Gleeson JGA, et al. BMJ 1988; 297: 163–6 |
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| Budesonide via Nebuhaler provided effective prophylaxis of asthma in patients aged 2–6 years with poorly-controlled asthma. Mean morning and evening PEF were significantly (p = 0.004) improved compared with placebo.
Budesonide via Nebuhaler improves morning and evening PEF compared with placebo

Adapted from Gleeson et al., 1988. |
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| 2. Bisgaard H, et al. Lancet 1990; 336: 649–51 |
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| Budesonide pMDI with Nebuhaler gives significant symptom relief and reduces the need for oral prednisolone compared with placebo in young children, aged 11–36 months, with recurrent wheezing. |
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| 3. Connett GJ, et al. Arch Dis Child 1993; 69: 351–55 |
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| Children, aged 1–3 years, with severe asthma had their daytime and night-time asthma symptoms significantly reduced by the use of inhaled budesonide pMDI via Nebuhaler compared with placebo. |
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| 4. Noble V, et al. Arch Dis Child 1992; 67: 285–8 |
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| Infants, aged under 18 months, with chronic wheeze experienced significant reduction in symptoms using budesinode pMDI via Nebuhaler compared with placebo.
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