| Delivery of drug to the lung was significantly greater when using Nebuhaler than when a pMDI was used alone and when simulated poor technique (inhalation 1 second after actuation) was used. Administration using pMDI alone simulated poor inhaler technique by inhaling 1 second after actuation. Multiple puffs consisted of four actuations separated 1 second apart.
Nebuhaler increases dose delivery to the lungs compared with pMDI alone
Administration using pMDI alone simulated poor inhaler technique by inhaling 1 second after actuation. Multiple puffs consisted of four actuations separated 1 second apart.
Adapted from Newman et al., 1984. |
