| The drug delivery from Nebuhaler was compared with that of a pMDI alone used with poor technique (actuation 1 second before inhalation). In nine adult patients with obstructive lung disease, Nebuhaler reduced oropharyngeal deposition compared with incorrectly-used pMDI alone.
Nebuhaler reduces oropharyngeal deposition compared with pMDI alone
Administration using pMDI alone simulated poor inhaler technique by inhaling 1 second after actuation. Multiple puffs consisted of four actuations separated 1 second apart. Adapted from Newman et al., 1984. |
